Linking location and action: mechanisms of Hox protein motif usage
The project aims at uncovering the molecular and cellular bases for Ubx and AbdA distinct motif usage.
INSTITUTE OF DEVELOPMENTAL BIOLOGY
The project aims at uncovering the molecular and cellular bases for Ubx and AbdA distinct motif usage.
During the Master’s project (M1 or M2), the student will use some of the techniques used in the laboratory to quantitatively interrogate the structure-function relationship underlying interallelic interactions.
The M1 student will learn micromanipulation, live confocal imaging, immunofluorescence and quantitative modelling techniques.
During this master project (M1 or M2), the student will analyze the dynamics of PRC1 dots during neuronal specification and maintenance by in vivo time-lapse imaging, and characterize the nature of these dots.
The successful completion of the project will allow you to answer how mechanical tension is generated inside human myofibers by integrating intracellular molecular forces and extracellular mechanical environment.
Project title: Investigating the mechanobiology of self-organisation in human iPSC-derived skeletal muscles Type of rotation: M1 (2 months) or M2 (6 months) Supervisors: Qiyan MAO