In the team “Local Translation in Axon Regeneration”, we investigate the molecular mechanisms that underlie the regenerative capacity of injured neurons. Our research focuses on gene regulation processes, particularly the translational control of mRNAs into proteins — an essential step for effective regeneration (Schaeffer et al., Neuron, 2023). A key aspect of our work is to understand how neurons regulate gene expression locally within axons through local ribosome supply and mRNA translation. The successful candidate will establish live imaging tools to analyse translation dynamics in regenerating axons, using an ex vivo culture model previously optimized (Schaeffer et al., Frontiers in Molecular Neuroscience, 2020).
12-month contract with possibility of renewal