Event Type: PhD defense

Muscles are crucial effectors of animal behaviour, as they translate neuronal signals into movement. Generally, most of the muscles are composed of structural and functional

Tumor innervation is increasingly recognized as a driver of cancer progression. Yet, the mechanisms that drive neural growth into tumors remain poorly understood. The aim

The morphology of dendrites shapes synaptic connectivity and therefore neuronal function. To better understand the principles governing the formation of dendritic arbors, we study two

Skeletal muscles, responsible for animal movement, are packed with the repeating functional unit characteristic of striated muscles: the sarcomere. Sarcomeres are super-assemblies of long and

Ciliary locomotion relies on local cellular components to generate coordinated movement, a strategy conserved from unicellular eukaryotes to metazoans. In most animals, the coordination and direction

Mechanical forces play a fundamental role in protein function, influencing how proteins fold, unfold (or stretch), and interact in biological systems. Specific sequence motifs and

Glioblastoma (GBM) is the most aggressive primary brain tumor in adults, marked by rapid proliferation, diffuse infiltration, and therapeutic resistance. Increasing evidence suggests that neural

Early mammalian development remains poorly understood, mainly due to the inaccessibility of embryos in utero. To overcome this limitation, recent studies have demonstrated that embryonic

Le toucher est l’un des sens le plus sollicité dès la naissance et demeure essentiel tout au long de la vie pour diverses fonctions, y

This thesis explores the biophysical and computational modeling of self-organization in gastruloids, three-dimensional in vitro models of embryonic development. It investigates how cellular decisions emerge