{"id":3746,"date":"2022-03-08T19:53:14","date_gmt":"2022-03-08T18:53:14","guid":{"rendered":"https:\/\/staging.wp-ibdm.nicolasg.fr\/les-bacteries-intestinales-regulent-le-metabolisme-des-lipides-dans-les-adipocytes\/"},"modified":"2022-07-09T11:00:27","modified_gmt":"2022-07-09T09:00:27","slug":"les-bacteries-intestinales-regulent-le-metabolisme-des-lipides-dans-les-adipocytes","status":"publish","type":"post","link":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/les-bacteries-intestinales-regulent-le-metabolisme-des-lipides-dans-les-adipocytes\/","title":{"rendered":"Les bact\u00e9ries intestinales r\u00e9gulent le m\u00e9tabolisme des lipides dans les adipocytes"},"content":{"rendered":"<p>Chez les eucaryotes les bact\u00e9ries intestinales influencent consid\u00e9rablement la physiologie de leur h\u00f4te. Chez la drosophile, ces effets sont m\u00e9di\u00e9s par les adipocytes qui exercent \u00e0 la fois une fonction immunitaire et m\u00e9tabolique. Nous avons d\u00e9couvert que l&#8217;infection ent\u00e9rique par certaines esp\u00e8ces de bact\u00e9ries d\u00e9clenche l&#8217;activation de la prot\u00e9ine lipog\u00e9nique SREBP (<span style=\"text-decoration: underline;\">S<\/span>terol\u00a0<span style=\"text-decoration: underline;\">R<\/span>egulatory<span style=\"text-decoration: underline;\">E<\/span>lement\u00a0<span style=\"text-decoration: underline;\">B<\/span>inding\u00a0<span style=\"text-decoration: underline;\">P<\/span>rotein) localement dans les ent\u00e9rocytes, et \u00e0 distance dans les cellules du corps gras et dans les ovaires, et que ces effets requi\u00e8rent l\u2019activation de la voie Insuline.<\/p>\n<p>Nos travaux d\u00e9montrent qu&#8217;en activant la voie NF-kB, le peptidoglycane de la paroi cellulaire produit par ces m\u00eames bact\u00e9ries,\u00a0contrecarre\u00a0l&#8217;activation de SREBP dans les adipocytes de mani\u00e8re autonome cellulaire. En r\u00e9duisant le niveau de peptidoglycane circulant, l&#8217;amidase PGRP-LB joue un r\u00f4le central dans l\u2019hom\u00e9ostasie des r\u00e9ponses immunitaires et m\u00e9taboliques de l&#8217;h\u00f4te\u00a0\u00e0 la pr\u00e9sence des bact\u00e9ries intestinales. En l&#8217;absence d&#8217;une telle modulation, l&#8217;activation incontr\u00f4l\u00e9e des voies immunitaires emp\u00eache l&#8217;activation de SREBP et la production de lipides par le corps gras.<\/p>\n<p><img fetchpriority=\"high\" decoding=\"async\" class=\"wp-image-10147 alignleft\" alt=\"Charroux-et-al\" src=\"https:\/\/staging.wp-ibdm.nicolasg.fr\/wp-content\/uploads\/2022\/03\/Charroux-et-al.jpg\" width=\"368\" height=\"368\" \/> <img decoding=\"async\" class=\"wp-image-10148\" alt=\"Charroux-et-al2\" src=\"https:\/\/staging.wp-ibdm.nicolasg.fr\/wp-content\/uploads\/2022\/03\/Charroux-et-al2.jpg\" width=\"368\" height=\"368\" \/><\/p>\n<h3>En savoir plus<\/h3>\n<p><a href=\"https:\/\/journals.plos.org\/plosgenetics\/article?id=10.1371\/journal.pgen.1010098\" target=\"_blank\" rel=\"noopener\">Charroux B, Royet J. Gut-derived peptidoglycan remotely inhibits bacteria dependent activation of SREBP by Drosophila adipocytes. PLoS Genet. 2022 Mar 4;18(3):e1010098. doi: 10.1371\/journal.pgen.1010098. Epub ahead of print. PMID: 35245295.<\/a><\/p>\n<h3>Contact<\/h3>\n<p><a href=\"mailto:bernard.charroux@univ-amu.fr\">Bernard Charroux<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Nos travaux d\u00e9montrent qu&#8217;en activant la voie NF-kB, le peptidoglycane de la paroi cellulaire produit par ces m\u00eames bact\u00e9ries, contrecarre l&#8217;activation de SREBP dans les adipocytes de mani\u00e8re autonome cellulaire. <\/p>\n","protected":false},"author":3,"featured_media":5546,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[39],"tags":[],"class_list":["post-3746","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-non-classifiee","ibdm_team-team-63"],"acf":[],"_links":{"self":[{"href":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/wp-json\/wp\/v2\/posts\/3746","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/wp-json\/wp\/v2\/comments?post=3746"}],"version-history":[{"count":1,"href":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/wp-json\/wp\/v2\/posts\/3746\/revisions"}],"predecessor-version":[{"id":11210,"href":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/wp-json\/wp\/v2\/posts\/3746\/revisions\/11210"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/wp-json\/wp\/v2\/media\/5546"}],"wp:attachment":[{"href":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/wp-json\/wp\/v2\/media?parent=3746"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/wp-json\/wp\/v2\/categories?post=3746"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/wp-json\/wp\/v2\/tags?post=3746"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}