{"id":3729,"date":"2021-08-03T14:17:26","date_gmt":"2021-08-03T12:17:26","guid":{"rendered":"https:\/\/staging.wp-ibdm.nicolasg.fr\/formation-of-polarized-contractile-interfaces-by-self-organized-toll-8-cirl-gpcr-asymmetry-2\/"},"modified":"2022-07-08T12:29:38","modified_gmt":"2022-07-08T10:29:38","slug":"formation-of-polarized-contractile-interfaces-by-self-organized-toll-8-cirl-gpcr-asymmetry-2","status":"publish","type":"post","link":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/formation-of-polarized-contractile-interfaces-by-self-organized-toll-8-cirl-gpcr-asymmetry-2\/","title":{"rendered":"Formation d&#8217;interfaces contractiles polaris\u00e9es par une asym\u00e9trie auto-organis\u00e9e des GPCR Toll-8\/Cirl."},"content":{"rendered":"<p>On savait que les r\u00e9cepteurs Toll et la signalisation des RCPG contr\u00f4laient l&#8217;activation de la myosine-II et la polarit\u00e9 planaire pendant l&#8217;extension de l&#8217;axe chez les embryons pr\u00e9coces de drosophile, mais on ignorait si et comment ils coop\u00e9raient dans ce processus Dans ce travail, Jules Lavalou, Qiyan Mao et leurs coll\u00e8gues de l&#8217;\u00e9quipe de Thomas Lecuit rapportent que Toll-8 contr\u00f4le la polarit\u00e9 planaire de la myosine-II dans les embryons et les disques alaires de drosophile via une interaction physique avec le GPCR Cirl\/latrophiline. Ils montrent que les limites d&#8217;expression de Toll-8 g\u00e9n\u00e8rent une asym\u00e9trie interfaciale Cirl et proposent qu&#8217;il s&#8217;agisse d&#8217;un signal potentiel conduisant \u00e0 la polarisation de la myosine-II.<\/p>\n<h3><img fetchpriority=\"high\" decoding=\"async\" class=\"aligncenter size-full wp-image-9788\" alt=\"Lavalou-et-al\" src=\"https:\/\/staging.wp-ibdm.nicolasg.fr\/wp-content\/uploads\/2021\/08\/Lavalou-et-al.png\" width=\"5000\" height=\"5000\"><\/h3>\n<h3>Pour en savoir plus :<\/h3>\n<ul>\n<li><a href=\"https:\/\/doi.org\/10.1016\/j.devcel.2021.03.030\" target=\"_blank\" rel=\"noopener\">Lavalou J, Mao Q, Harmansa S, Kerridge S, Lellouch AC, Philippe JM, Audebert S, Camoin L, Lecuit T.<br \/>\nFormation d&#8217;interfaces contractiles polaris\u00e9es par une asym\u00e9trie auto-organis\u00e9e des GPCR Toll-8\/Cirl.<br \/>\nDev Cell. 2021 Jun 7;56(11):1574-1588.e7. doi: 10.1016\/j.devcel.2021.03.030. Epub 2021 Apr 30. PMID: 33932333; PMCID: PMC8207821.<\/a><\/li>\n<\/ul>\n<h3>Contact<\/h3>\n<p><strong>Thomas Lecuit :<\/strong> <a href=\"mailto:thomas.lecuit@univ-amu.fr\">thomas.lecuit@univ-amu.fr<\/a><\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Jules Lavalou and Qiyan Mao from Thomas Lecuit\u2019s team report that Toll-8 controls myosin-II planar polarity in Drosophila embryos and wing discs via a physical interaction with the GPCR Cirl\/latrophilin.<\/p>\n","protected":false},"author":3,"featured_media":5513,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[79],"tags":[],"class_list":["post-3729","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news-fr","ibdm_team-team-6"],"acf":[],"_links":{"self":[{"href":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/wp-json\/wp\/v2\/posts\/3729","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/wp-json\/wp\/v2\/comments?post=3729"}],"version-history":[{"count":1,"href":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/wp-json\/wp\/v2\/posts\/3729\/revisions"}],"predecessor-version":[{"id":11147,"href":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/wp-json\/wp\/v2\/posts\/3729\/revisions\/11147"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/wp-json\/wp\/v2\/media\/5513"}],"wp:attachment":[{"href":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/wp-json\/wp\/v2\/media?parent=3729"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/wp-json\/wp\/v2\/categories?post=3729"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/wp-json\/wp\/v2\/tags?post=3729"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}