{"id":3699,"date":"2020-12-23T16:16:45","date_gmt":"2020-12-23T15:16:45","guid":{"rendered":"https:\/\/staging.wp-ibdm.nicolasg.fr\/regulatory-encoding-of-quantitative-variation-in-spatial-activity-of-a-drosophila-enhancer-2\/"},"modified":"2022-07-09T11:40:07","modified_gmt":"2022-07-09T09:40:07","slug":"regulatory-encoding-of-quantitative-variation-in-spatial-activity-of-a-drosophila-enhancer-2","status":"publish","type":"post","link":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/regulatory-encoding-of-quantitative-variation-in-spatial-activity-of-a-drosophila-enhancer-2\/","title":{"rendered":"Regulatory encoding of quantitative variation in spatial activity of a Drosophila enhancer"},"content":{"rendered":"<p>Une publication de l&#8217;\u00e9quipe de Benjamin Prud&#8217;homme, en collaboration avec celle de N. Gompel (LMU, Munich,) explore de la relation entre les informations quantitatives l\u2019activit\u00e9 spatiale cod\u00e9es par les s\u00e9quences cis-r\u00e9gulatrices d&#8217;un g\u00e8ne de d\u00e9veloppement. Les auteurs ont introduit des mutations syst\u00e9matiques dans la s\u00e9quence cis-r\u00e9gulatrice d\u2019un g\u00e8ne de drosophile afin d&#8217;interroger la relation entre la structure de cette s\u00e9quence et sa fonction. En utilisant des approches quantitatives des profils d&#8217;expression g\u00e9nique, les auteurs ont r\u00e9v\u00e9l\u00e9 une densit\u00e9 inattendue d&#8217;informations r\u00e9gulatrices le long de la s\u00e9quence cis-r\u00e9gulatrice. Cette analyse r\u00e9v\u00e8le la relation complexe entre les niveaux d&#8217;activit\u00e9 d&#8217;une s\u00e9quence cis-r\u00e9gulatrice dans les diff\u00e9rentes cellules dans lesquelles elle est active et le profil spatial \u00e9mergeant de cette mosa\u00efque de niveaux d&#8217;expression.<\/p>\n<p style=\"text-align: center;\"><a href=\"https:\/\/staging.wp-ibdm.nicolasg.fr\/wp-content\/uploads\/2020\/12\/LePoul-et-al_Science-Advances.png\"><img fetchpriority=\"high\" decoding=\"async\" class=\"aligncenter  wp-image-9403\" alt=\"LePoul-et-al_Science Advances\" src=\"https:\/\/staging.wp-ibdm.nicolasg.fr\/wp-content\/uploads\/2020\/12\/LePoul-et-al_Science-Advances.png\" width=\"1660\" height=\"1156\" \/><\/a><\/p>\n<h3>En Savoir Plus :<\/h3>\n<ul>\n<li><a href=\"https:\/\/advances.sciencemag.org\/content\/6\/49\/eabe2955\" target=\"_blank\" rel=\"noopener\">Regulatory encoding of quantitative variation in spatial activity of a Drosophila enhancer<\/a><\/li>\n<\/ul>\n<p><a href=\"https:\/\/advances.sciencemag.org\/content\/6\/49\/eabe2955\" target=\"_blank\" rel=\"noopener\">Yann Le Poul<sup>\u2020<\/sup>, Yaqun Xin<sup>\u2020<\/sup>, Liucong Ling,\u00a0Bettina M\u00fchling, Rita Jaenichen,\u00a0David H\u00f6rl,\u00a0David Bunk, Hartmann Harz, Heinrich Leonhardt, Yingfei Wang, Elena Osipova, Mariam Museridze, Deepak Dharmadhikari,\u00a0Eamonn Murphy, Remo Rohs, Stephan Preibisch, Benjamin Prud\u2019homme* and Nicolas Gompel*<\/a><\/p>\n<p><cite>Science Advances\u00a0<\/cite>\u00a002 Dec 2020:Vol. 6, no. 49, eabe2955 DOI: 10.1126\/sciadv.<\/p>\n<ul>\n<li>\n<h5>Contact<\/h5>\n<\/li>\n<\/ul>\n<p><strong>Benjamin Prud\u2019homme &#8211;<\/strong>\u00a0<a href=\"mailto:Benjamin.prudhomme@univ-amu.fr\">Benjamin.prudhomme@univ-amu.fr<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Une publication de l&#8217;\u00e9quipe de Benjamin Prud&#8217;homme, en collaboration avec celle de N. Gompel, explore de la relation entre les informations quantitatives l\u2019activit\u00e9 spatiale cod\u00e9es par les s\u00e9quences cis-r\u00e9gulatrices d&#8217;un g\u00e8ne de d\u00e9veloppement.<\/p>\n","protected":false},"author":3,"featured_media":5453,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[79],"tags":[],"class_list":["post-3699","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news-fr","ibdm_team-team-98"],"acf":[],"_links":{"self":[{"href":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/wp-json\/wp\/v2\/posts\/3699","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/wp-json\/wp\/v2\/comments?post=3699"}],"version-history":[{"count":1,"href":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/wp-json\/wp\/v2\/posts\/3699\/revisions"}],"predecessor-version":[{"id":11244,"href":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/wp-json\/wp\/v2\/posts\/3699\/revisions\/11244"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/wp-json\/wp\/v2\/media\/5453"}],"wp:attachment":[{"href":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/wp-json\/wp\/v2\/media?parent=3699"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/wp-json\/wp\/v2\/categories?post=3699"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/wp-json\/wp\/v2\/tags?post=3699"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}