{"id":3683,"date":"2020-02-04T19:05:18","date_gmt":"2020-02-04T18:05:18","guid":{"rendered":"https:\/\/staging.wp-ibdm.nicolasg.fr\/loss-of-bhlha9-impairs-thermotaxis-and-formalin-evoked-pain-in-a-sexually-dimorphic-manner-2\/"},"modified":"2022-07-09T12:04:49","modified_gmt":"2022-07-09T10:04:49","slug":"loss-of-bhlha9-impairs-thermotaxis-and-formalin-evoked-pain-in-a-sexually-dimorphic-manner-2","status":"publish","type":"post","link":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/loss-of-bhlha9-impairs-thermotaxis-and-formalin-evoked-pain-in-a-sexually-dimorphic-manner-2\/","title":{"rendered":"Loss of bhlha9 impairs thermotaxis and formalin-evoked pain in a sexually dimorphic manner"},"content":{"rendered":"
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Article en anglais<\/em><\/p>\n

An intriguing subset of skin sensory neurons, called C-Low Threshold MechanoReceptors or C-LTMRs, is the main transducer of affective social touch. And in the last decade, studies in mouse and human suggest another role for these neurons as pain modulators.<\/p>\n<\/div>\n

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In their study published January 21 in Cell Reports, Bohic and colleagues confirm the role of C-LTMRs in inflammatory pain modulation by inactivating the transcription factor bhlha9 particularly enriched in these touch neurons.<\/p>\n<\/div>\n

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Moreover, by comparing the behavior, physiology and molecular profile of the somatosensory nervous system of mutant male and female mice, they show for the first time a profound sexual dimorphism in the way peripheral and spinal networks are activated and modulate inflammatory pain.<\/p>\n<\/div>\n

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En savoir plus :<\/h3>\n