{"id":3681,"date":"2019-11-19T09:40:00","date_gmt":"2019-11-19T08:40:00","guid":{"rendered":"https:\/\/staging.wp-ibdm.nicolasg.fr\/lequipe-maina-en-collaboration-avec-avec-lequipe-de-recherche-imxgam-cppm-et-des-chercheurs-du-ciml-et-de-cerimed-publie-dans-iscience\/"},"modified":"2022-07-09T11:31:40","modified_gmt":"2022-07-09T09:31:40","slug":"lequipe-maina-en-collaboration-avec-avec-lequipe-de-recherche-imxgam-cppm-et-des-chercheurs-du-ciml-et-de-cerimed-publie-dans-iscience","status":"publish","type":"post","link":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/lequipe-maina-en-collaboration-avec-avec-lequipe-de-recherche-imxgam-cppm-et-des-chercheurs-du-ciml-et-de-cerimed-publie-dans-iscience\/","title":{"rendered":"L’\u00e9quipe Maina, en collaboration avec avec l\u2019\u00e9quipe de recherche imXgam (CPPM) et des chercheurs du CIML et de Cerimed, publie dans iScience"},"content":{"rendered":"

Post en anglais<\/em><\/p>\n

Researchers have used the CERN pixels to follow tumour evolution in a liver cancer mouse model.<\/h3>\n

A photon counting scanner has been developed by engineers and physicists at the CPPM for longitudinal in vivo imaging studies with Maina Team to follow for several months the tumour growth of mice spontaneously developing liver tumours. We found a remarkable heterogeneity in the dynamics for tumours at the initiation phases, whereas the growth curve of evolving tumours exhibited a comparable exponential growth, with a constant doubling time. Furthermore, this PC-CT imaging system demonstrated the effectiveness of a combinatorial therapy leading to a drastic tumour regression accompanied by a striking remodelling of macrophages in the tumour microenvironment. This interdisciplinary study was published in the journal iScience<\/i>.<\/p>\n

\"Maina-publication\"<\/a>
Diagram illustrating the application of this new imaging system for small animals, which allows a complete analysis of the animal body. The mice are injected with a contrast agent such as barium. Photons emitted by X-rays are quantified by micro-computed tomography (PC-CT). The acquired data can then be used to visualize organs with images (transverse, longitudinal, sagittal), which can also be used for 3D reconstruction. This PC-CT system has been applied to a mouse model that recapitulates the tumorigenesis of liver cancer patients, to visualize tumours at the stage of their formation and to follow their evolution over time (up to 3 months). This PC-CT system has also been used to study the efficacy of a new combination of anticancer agents, which effectiveness is illustrated by tumour regression and by remodelling of the tumour microenvironment (notably the recruitment of macrophages).<\/figcaption><\/figure>\n

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To know more :<\/h3>\n