{"id":3673,"date":"2019-11-01T16:29:39","date_gmt":"2019-11-01T15:29:39","guid":{"rendered":"https:\/\/staging.wp-ibdm.nicolasg.fr\/peptidoglycan-dependent-nf-%ce%bab-activation-in-a-small-subset-of-brain-octopaminergic-neurons-controls-female-oviposition-2\/"},"modified":"2022-07-09T11:03:29","modified_gmt":"2022-07-09T09:03:29","slug":"peptidoglycan-dependent-nf-%ce%bab-activation-in-a-small-subset-of-brain-octopaminergic-neurons-controls-female-oviposition-2","status":"publish","type":"post","link":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/peptidoglycan-dependent-nf-%ce%bab-activation-in-a-small-subset-of-brain-octopaminergic-neurons-controls-female-oviposition-2\/","title":{"rendered":"Peptidoglycan-dependent NF-\u03baB activation in a small subset of brain octopaminergic neurons controls female oviposition"},"content":{"rendered":"<p><a href=\"https:\/\/staging.wp-ibdm.nicolasg.fr\/wp-content\/uploads\/2019\/11\/ROYETexp.jpg\"><img fetchpriority=\"high\" decoding=\"async\" class=\"size-medium wp-image-8828 alignright\" alt=\"ROYETexp\" src=\"https:\/\/staging.wp-ibdm.nicolasg.fr\/wp-content\/uploads\/2019\/11\/ROYETexp-300x224.jpg\" width=\"300\" height=\"224\" \/><\/a>Les eucaryotes vivent en \u00e9troite association avec les microorganismes qui prolif\u00e8rent dans l\u2019environnement. Si certains, comme les bact\u00e9ries commensales qui colonisent l\u2019intestin des animaux peuvent \u00eatre b\u00e9n\u00e9fiques, d\u2019autres sont pathog\u00e8nes et potentiellement dangereuses pour l\u2019h\u00f4te. Les animaux ont donc \u00e9labor\u00e9, au cours du temps, des m\u00e9canismes qui limitent les risques d\u2019infection par les microbes potentiellement n\u00e9fastes. Si cette premi\u00e8re \u00e9tape \u00e9choue, l\u2019h\u00f4te infect\u00e9 d\u00e9clenche une r\u00e9ponse immunitaire qui \u00e9radique le pathog\u00e8ne. De nombreuses \u00e9vidences sugg\u00e8rent, qu\u2019en parall\u00e8le de cette immunit\u00e9 \u00ab\u00a0classique\u00a0\u00bb, l\u2019h\u00f4te infect\u00e9 modifie son comportement pour limiter au maximum les cons\u00e9quences de cette infection sur lui-m\u00eame ou sur sa descendance. Cette immunit\u00e9, dite comportementale, n\u00e9cessite un dialogue entre l\u2019agent infectieux et syst\u00e8me nerveux de l\u2019h\u00f4te.<\/p>\n<p><a href=\"https:\/\/staging.wp-ibdm.nicolasg.fr\/wp-content\/uploads\/2019\/11\/ROYET2exp.jpg\"><img decoding=\"async\" class=\"size-medium wp-image-8827 alignleft\" alt=\"ROYET2exp\" src=\"https:\/\/staging.wp-ibdm.nicolasg.fr\/wp-content\/uploads\/2019\/11\/ROYET2exp-300x224.jpg\" width=\"300\" height=\"224\" \/><\/a>L\u2019\u00e9quipe de Julien Royet utilise les outils g\u00e9n\u00e9tiques g\u00e9n\u00e9r\u00e9s chez l\u2019insecte drosophile pour diss\u00e9quer les interactions mol\u00e9culaires entre les bact\u00e9ries et le syst\u00e8me nerveux de l\u2019h\u00f4te. Dans un article dont les auteurs principaux sont Ambra Masuzzo et L\u00e9opold Kurz, l\u2019\u00e9quipe d\u00e9montre que la d\u00e9tection directe d\u2019un composant de la paroi bact\u00e9rienne appel\u00e9 peptidoglycane, par seulement 2 neurones octopaminergiques sur les quelques 100.000 que contient le cerveau de la mouche, suffit \u00e0 modifier le comportement des drosophiles femelles infect\u00e9es. En inhibant l\u2019activit\u00e9 de ces deux neurones, le peptidoglycane r\u00e9duit la ponte des mouches infect\u00e9es, leur permettant d\u2019allouer plus d\u2019\u00e9nergie \u00e0 l\u2019\u00e9limination du pathog\u00e8ne.<\/p>\n<h5>En Savoir Plus :<\/h5>\n<ul>\n<li>\n<h3><a href=\"https:\/\/elifesciences.org\/articles\/50559\" target=\"_blank\" rel=\"noopener\">Peptidoglycan-dependent NF-\u03baB activation in a small subset of brain octopaminergic neurons controls female oviposition.<\/a><\/h3>\n<p><b>Ambra Masuzzo, G\u00e9rard Mani\u00e8re, Annelise Viallat-Lieutaud, \u00c9milie Avazeri, Olivier Zugasti, Ya\u00ebl Grosjean, C L\u00e9opold Kurz, Julien Royet<\/b><\/li>\n<li>\n<h3><a href=\"https:\/\/insb.cnrs.fr\/fr\/cnrsinfo\/comment-les-bacteries-modifient-elles-le-comportement-des-drosophiles\" target=\"_blank\" rel=\"noopener\">Article sur le site du CNRS<\/a><\/h3>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h5><\/h5>\n","protected":false},"excerpt":{"rendered":"<p>Julien Royet&#8217;s team uses the genetic tools generated in the fruit fly to dissect the molecular interactions between bacteria and the host&#8217;s nervous system.<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[79],"tags":[],"class_list":["post-3673","post","type-post","status-publish","format-standard","hentry","category-news-fr","ibdm_team-team-63"],"acf":[],"_links":{"self":[{"href":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/wp-json\/wp\/v2\/posts\/3673","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/wp-json\/wp\/v2\/comments?post=3673"}],"version-history":[{"count":1,"href":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/wp-json\/wp\/v2\/posts\/3673\/revisions"}],"predecessor-version":[{"id":11212,"href":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/wp-json\/wp\/v2\/posts\/3673\/revisions\/11212"}],"wp:attachment":[{"href":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/wp-json\/wp\/v2\/media?parent=3673"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/wp-json\/wp\/v2\/categories?post=3673"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/wp-json\/wp\/v2\/tags?post=3673"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}