{"id":359,"date":"2022-04-29T11:17:01","date_gmt":"2022-04-29T09:17:01","guid":{"rendered":"https:\/\/staging.wp-ibdm.nicolasg.fr\/?p=359"},"modified":"2023-01-17T17:40:04","modified_gmt":"2023-01-17T16:40:04","slug":"targeted-tshz3-deletion-in-corticostriatal-circuit-components-segregates-core-autistic-behaviors","status":"publish","type":"post","link":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/targeted-tshz3-deletion-in-corticostriatal-circuit-components-segregates-core-autistic-behaviors\/","title":{"rendered":"Targeted Tshz3 deletion in corticostriatal circuit components segregates core autistic behaviors"},"content":{"rendered":"<p>Nous avons pr\u00e9c\u00e9demment \u00e9tabli un lien entre l\u2019haploinsuffisance de&nbsp;<i>TSHZ3<\/i>&nbsp;et le trouble du spectre de l\u2019autisme (TSA) et montr\u00e9 que la d\u00e9l\u00e9tion embryonnaire ou postnatale de&nbsp;<i>Tshz3<\/i>&nbsp;chez la souris entra\u00eene des alt\u00e9rations du comportement typique du TSA : d\u00e9ficits d\u2019interaction sociale et comportements r\u00e9p\u00e9titifs.<\/p>\n<p>Nous montrons ici que l\u2019\u00e9limination de&nbsp;<i>Tshz3<\/i>&nbsp;dans les neurones de projection corticaux (CPN) ou dans les interneurones cholinergiques striataux (SCIN) n\u2019affecte pas leurs nombres, mais modifie leurs propri\u00e9t\u00e9s \u00e9lectrophysiologiques et le fonctionnement du circuit corticostri\u00e9. De plus, la perte de&nbsp;<i>Tshz3<\/i>&nbsp;dans les CPN entra\u00eene des d\u00e9ficits d\u2019interaction sociale, tandis que son \u00e9limination dans les SCIN entra\u00eene des comportements r\u00e9p\u00e9titifs. Par cons\u00e9quent, le dysfonctionnement des CPN ou des SCIN est associ\u00e9 \u00e0 un trait comportemental distinct des TSA.<\/p>\n<p>Ces r\u00e9sultats apportent un \u00e9clairage nouveau sur l\u2019implication du circuit corticostri\u00e9 dans les TSA en r\u00e9v\u00e9lant une dichotomie inattendue dans les substrats neuronaux des deux domaines comportementaux caract\u00e9ristiques de ce trouble.<\/p>\n<p><a href=\"https:\/\/staging.wp-ibdm.nicolasg.fr\/wp-content\/uploads\/2022\/04\/Fasano_et_al.jpg\" data-elementor-open-lightbox=\"yes\" data-elementor-lightbox-title=\"Fasano_et_al\"><img fetchpriority=\"high\" decoding=\"async\" src=\"https:\/\/staging.wp-ibdm.nicolasg.fr\/wp-content\/uploads\/2022\/04\/Fasano_et_al.jpg\" sizes=\"(max-width: 2520px) 100vw, 2520px\" srcset=\"https:\/\/staging.wp-ibdm.nicolasg.fr\/wp-content\/uploads\/2022\/04\/Fasano_et_al.jpg 2520w, https:\/\/staging.wp-ibdm.nicolasg.fr\/wp-content\/uploads\/2022\/04\/Fasano_et_al-300x198.jpg 300w, https:\/\/staging.wp-ibdm.nicolasg.fr\/wp-content\/uploads\/2022\/04\/Fasano_et_al-1024x674.jpg 1024w, https:\/\/staging.wp-ibdm.nicolasg.fr\/wp-content\/uploads\/2022\/04\/Fasano_et_al-768x506.jpg 768w, https:\/\/staging.wp-ibdm.nicolasg.fr\/wp-content\/uploads\/2022\/04\/Fasano_et_al-1536x1011.jpg 1536w, https:\/\/staging.wp-ibdm.nicolasg.fr\/wp-content\/uploads\/2022\/04\/Fasano_et_al-2048x1348.jpg 2048w\" alt=\"\" width=\"2520\" height=\"1659\"> <\/a><\/p>\n<h3>En savoir plus<\/h3>\n<p><a href=\"https:\/\/www.nature.com\/articles\/s41398-022-01865-6\" target=\"_blank\" rel=\"noopener\">Caubit, X., Gubellini, P., Roubertoux, P.L.&nbsp;<i>et al.<\/i>&nbsp;Targeted&nbsp;<i>Tshz3<\/i>&nbsp;deletion in corticostriatal circuit components segregates core autistic behaviors.&nbsp;<i>Transl Psychiatry<\/i>&nbsp;12,&nbsp;106 (2022). https:\/\/doi.org\/10.1038\/s41398-022-01865-6<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Nos r\u00e9sultats apportent un \u00e9clairage nouveau sur l\u2019implication du circuit corticostri\u00e9 dans les TSA.<\/p>\n","protected":false},"author":3,"featured_media":361,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"elementor_theme","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[78,10],"tags":[],"class_list":["post-359","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","category-research","ibdm_team-team-2"],"acf":[],"_links":{"self":[{"href":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/wp-json\/wp\/v2\/posts\/359","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/wp-json\/wp\/v2\/comments?post=359"}],"version-history":[{"count":4,"href":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/wp-json\/wp\/v2\/posts\/359\/revisions"}],"predecessor-version":[{"id":11405,"href":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/wp-json\/wp\/v2\/posts\/359\/revisions\/11405"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/wp-json\/wp\/v2\/media\/361"}],"wp:attachment":[{"href":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/wp-json\/wp\/v2\/media?parent=359"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/wp-json\/wp\/v2\/categories?post=359"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/wp-json\/wp\/v2\/tags?post=359"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}