{"id":23254,"date":"2026-03-02T12:11:09","date_gmt":"2026-03-02T11:11:09","guid":{"rendered":"https:\/\/staging.wp-ibdm.nicolasg.fr\/?p=23254"},"modified":"2026-03-02T12:19:46","modified_gmt":"2026-03-02T11:19:46","slug":"keynote-seminar-meritxell-huch-avancees-sur-les-organoides-derives-de-tissus","status":"publish","type":"post","link":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/keynote-seminar-meritxell-huch-avancees-sur-les-organoides-derives-de-tissus\/","title":{"rendered":"Keynote Seminar: Meritxell Huch | Avanc\u00e9es sur les organo\u00efdes d\u00e9riv\u00e9s de tissus"},"content":{"rendered":"\t\t
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Meritxell Huch est une biologiste de renomm\u00e9e internationale sp\u00e9cialis\u00e9e dans la biologie des cellules souches et le d\u00e9veloppement de mod\u00e8les d\u2019organo\u00efdes 3D, qu\u2019elle utilise pour d\u00e9crypter les m\u00e9canismes fondamentaux de la r\u00e9g\u00e9n\u00e9ration tissulaire et des maladies humaines, notamment du foie, de l\u2019estomac et du pancr\u00e9as. Apr\u00e8s un doctorat en biologie \u00e0 l\u2019Universit\u00e9 de Barcelone, elle s\u2019est rapidement distingu\u00e9e par des travaux pionniers men\u00e9s durant son post-doctorat aux Pays-Bas, avant de diriger sa propre \u00e9quipe au Gurdon Institute \u00e0 Cambridge.<\/p>

Son excellence scientifique a \u00e9t\u00e9 salu\u00e9e par de nombreuses distinctions prestigieuses et par sa nomination comme directrice au Max Planck Institute of Molecular Cell Biology and Genetics, o\u00f9 elle conduit aujourd\u2019hui une recherche de pointe \u00e0 l\u2019\u00e9chelle internationale.<\/p>

Si vous souhaitez en savoir plus, vous pouvez \u00e9couter son interview sur la r\u00e9g\u00e9n\u00e9ration h\u00e9patique<\/strong> dans \u00ab The Stem Cell Podcast \u00bb<\/a><\/strong>.<\/p>

\ud83d\udd67 Vendredi 13\/03\/2026 \u00e0 11h30 | Amphi 12
\ud83e\uddeb Tissue-Derived Organoids: Where We Stand and Where We Go<\/h6>

R\u00e9sum\u00e9 <\/strong>(en anglais<\/em>) :<\/strong><\/p>

In vitro 3D organoid cultures are emerging as novel systems to study tissue development, organogenesis, and stem cell behavior ex-vivo. Organoids are multicellular structures that (1) self-assemble and can be clonally expanded, (2) resemble the corresponding tissues-of-origin, and (3) allow the study of some aspects of tissue development and tissue physiology in a dish.<\/p>

Over the past decade, we have developed organoid cultures from healthy and diseased, human and mouse, adult and embryonic tissues for a range of organs including stomach, liver and pancreas. These, have allowed, for the first time, the long-term expansion of adult (stomach, liver and pancreas) tissues in a dish, thus defying the Hayflick limit, by which only cancer cells with aberrant ploidy and unstable genomes would expand in culture.<\/p>

Here, I will present our organoid work and summarize our findings on how this culture sys\u00adtem is amenable for the study of adult tissue regeneration and disease across different biologi\u00adcal scales. At the cellular scale, we have recently found that heterotypic cellular interactions between stromal and epithelial cells dictate the behavior of the liver epithelia, thus reconciling the apparent dichotomy between a pro-regenerative and a pro-quiescent stromal niche. At the molecular scale, we have found that a transient, genome-wide remodeling, of the cells\u2019 epige\u00adnome (DNA methylome\/hydroxymethylome), licenses adult differentiated liver cells to reprogram into bi-potent liver progenitors, both during organoid initiation and in vivo, follow\u00ading tissue damage. Our results indicate that adult tissue derived organoid cultures represent novel, reductionist in vitro models, that enable gaining mechanistic understanding of basic biological principles of human tissue regeneration and cancer.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"

Nous avons l’honneur d’accueillir Meritxell Huch comme keynote speaker le 13 mars 2026. Un \u00e9v\u00e9nement scientifique exceptionnel \u00e0 ne pas manquer ! <\/p>\n","protected":false},"author":27,"featured_media":23259,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[79],"tags":[],"class_list":["post-23254","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news-fr"],"acf":[],"_links":{"self":[{"href":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/wp-json\/wp\/v2\/posts\/23254","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/wp-json\/wp\/v2\/users\/27"}],"replies":[{"embeddable":true,"href":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/wp-json\/wp\/v2\/comments?post=23254"}],"version-history":[{"count":6,"href":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/wp-json\/wp\/v2\/posts\/23254\/revisions"}],"predecessor-version":[{"id":23274,"href":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/wp-json\/wp\/v2\/posts\/23254\/revisions\/23274"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/wp-json\/wp\/v2\/media\/23259"}],"wp:attachment":[{"href":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/wp-json\/wp\/v2\/media?parent=23254"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/wp-json\/wp\/v2\/categories?post=23254"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/wp-json\/wp\/v2\/tags?post=23254"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}