{"id":22015,"date":"2025-09-15T11:38:38","date_gmt":"2025-09-15T09:38:38","guid":{"rendered":"https:\/\/staging.wp-ibdm.nicolasg.fr\/?p=22015"},"modified":"2025-11-20T11:45:19","modified_gmt":"2025-11-20T10:45:19","slug":"precancer-linfluence-du-systeme-nerveux","status":"publish","type":"post","link":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/precancer-linfluence-du-systeme-nerveux\/","title":{"rendered":"Pr\u00e9cancer : l\u2019influence du syst\u00e8me nerveux"},"content":{"rendered":"\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t
\n\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t\t\t\t\t

Figure :<\/strong> reconstruction d\u2019une l\u00e9sion pr\u00e9canc\u00e9reuse (jaune) et de son r\u00e9seau d\u2019innervation sympathique (axones en vert, points de branchement en rose), \u00e0 partir d\u2019images 3D obtenues par microscopie de fluorescence \u00e0 feuille de lumi\u00e8re.<\/em><\/p>

Le syst\u00e8me nerveux ne se limite pas \u00e0 transmettre des signaux entre le cerveau et le corps : il interagit activement avec les tissus et influence leur int\u00e9grit\u00e9. Dans le pancr\u00e9as, les fibres nerveuses sympathiques se r\u00e9organisent autour des premi\u00e8res l\u00e9sions pr\u00e9canc\u00e9reuses, bien avant l\u2019apparition d\u2019un cancer. Cette \u00e9tude, men\u00e9e par Hiba Haidar et ses coll\u00e8gues \u00e0 l\u2019IBDM en collaboration avec l\u2019\u00e9quipe de Patrick Mehlen, montre que ce remodelage est orchestr\u00e9 par N\u00e9trine-1, une mol\u00e9cule de guidage axonal produite par les cellules des l\u00e9sions pr\u00e9canc\u00e9reuses. N\u00e9trine-1 stimule la croissance et la ramification des fibres nerveuses, formant un r\u00e9seau qui module la prolif\u00e9ration des cellules pr\u00e9canc\u00e9reuses. Lorsque N\u00e9trine-1 est inhib\u00e9e, la plasticit\u00e9 nerveuse diminue et les l\u00e9sions se d\u00e9veloppent plus rapidement. Ainsi, la plasticit\u00e9 nerveuse constitue un m\u00e9canisme protecteur lors des premi\u00e8res \u00e9tapes de la carcinogen\u00e8se pancr\u00e9atique. Ces r\u00e9sultats pourraient ouvrir de nouvelles perspectives pour la d\u00e9tection pr\u00e9coce des l\u00e9sions pr\u00e9canc\u00e9reuses et pour freiner leur progression vers le cancer.<\/p>

Haidar H, Bellon A, Sleiman K, Hocine M, Rama N, Gadot N, Carpizo DR, Mehlen P, Mann F. Neural function of Netrin-1 in precancerous lesions of the pancreas.<\/a> Nat Commun. 2025 Aug 2;16(1):7094. doi: 10.1038\/s41467-025-62299-4.\u00a0<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

\n\t\t\t\t
\n\t\t\t\t\t\t\t\t\t
\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\tRencontrer l'\u00e9quipe<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t
\n\t\t\t
\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"

La plasticit\u00e9 des nerfs sympathiques freine la formation des l\u00e9sions pr\u00e9canc\u00e9reuses du pancr\u00e9as.<\/p>\n","protected":false},"author":27,"featured_media":22019,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[79,132],"tags":[],"class_list":["post-22015","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news-fr","category-recherche","ibdm_team-team-105"],"acf":[],"_links":{"self":[{"href":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/wp-json\/wp\/v2\/posts\/22015","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/wp-json\/wp\/v2\/users\/27"}],"replies":[{"embeddable":true,"href":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/wp-json\/wp\/v2\/comments?post=22015"}],"version-history":[{"count":8,"href":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/wp-json\/wp\/v2\/posts\/22015\/revisions"}],"predecessor-version":[{"id":22034,"href":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/wp-json\/wp\/v2\/posts\/22015\/revisions\/22034"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/wp-json\/wp\/v2\/media\/22019"}],"wp:attachment":[{"href":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/wp-json\/wp\/v2\/media?parent=22015"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/wp-json\/wp\/v2\/categories?post=22015"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/wp-json\/wp\/v2\/tags?post=22015"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}