{"id":21598,"date":"2025-05-16T15:42:46","date_gmt":"2025-05-16T13:42:46","guid":{"rendered":"https:\/\/staging.wp-ibdm.nicolasg.fr\/?p=21598"},"modified":"2025-05-19T10:18:37","modified_gmt":"2025-05-19T08:18:37","slug":"une-percee-dans-letude-des-microarn","status":"publish","type":"post","link":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/une-percee-dans-letude-des-microarn\/","title":{"rendered":"Une perc\u00e9e dans l&#8217;\u00e9tude des microARN"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"21598\" class=\"elementor elementor-21598 elementor-21597\" data-elementor-post-type=\"post\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-5bde5cc elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"5bde5cc\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-d21b590\" data-id=\"d21b590\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-131c12e elementor-widget elementor-widget-text-editor\" data-id=\"131c12e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p data-renderer-start-pos=\"1256\"><strong>Figure :<\/strong> <em>Carte thermique illustrant l&#8217;enrichissement en microARNs dans les trois principaux types de cellules du cerveau en d\u00e9veloppement de la drosophile : la glie, les neurones et les prog\u00e9niteurs neuronaux.<\/em><\/p><p data-renderer-start-pos=\"220\"><strong>Les chercheurs de l&#8217;IBDM ont d\u00e9velopp\u00e9 une nouvelle technique, appel\u00e9e \u00ab in vivo AGO-APP \u00bb, qui permet une description compl\u00e8te des microARN actifs exprim\u00e9s dans les diff\u00e9rents types de cellules d&#8217;un tissu.<\/strong><\/p><p data-renderer-start-pos=\"220\">En l&#8217;appliquant au cerveau en d\u00e9veloppement de la <em data-renderer-mark=\"true\">drosophile<\/em>, ils ont pu identifier un module de miARN exprim\u00e9s dans les cellules souches neurales, qui r\u00e9duisent au silence un r\u00e9seau de g\u00e8nes impliqu\u00e9s dans la diff\u00e9renciation neuronale. Les r\u00e9sultats sugg\u00e8rent que l&#8217;efficacit\u00e9 et la sp\u00e9cificit\u00e9 du ciblage des ARNm par les microARN d\u00e9pendent de leur mode d&#8217;action coop\u00e9ratif. Ces travaux ouvrent la voie \u00e0 la manipulation pr\u00e9cise de r\u00e9seaux de g\u00e8nes entiers par le contr\u00f4le de l&#8217;activit\u00e9 des ARNm.  <\/p><p data-renderer-start-pos=\"865\"><strong>Ce travail est une collaboration fructueuse entre les \u00e9quipes des professeurs <a href=\"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/team\/controle-moleculaire-de-la-neurogenese\/\" target=\"_blank\" rel=\"noopener\">Cremer<\/a> et <a href=\"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/team\/plasticite-des-cellules-souches-neurales-chez-la-drosophile\/\" target=\"_blank\" rel=\"noopener\">Maurange<\/a>.<\/strong><\/p><p data-renderer-start-pos=\"947\">Narbonne-Reveau* K, Erni* A, Eichner N, Sankar S, Kapoor S, Meister G, Cremer H, Maurange C, Beclin C. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40299997\/\" target=\"_blank\" rel=\"noopener\">In vivo AGO-APP identifies a module of microRNAs cooperatively preserving neural progenitors.<\/a> PLoS Genet. 2025 Apr 29;21(4):e1011680.  <\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-ebb49e8 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"ebb49e8\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-43974af\" data-id=\"43974af\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>L&#8217;in vivo AGO-APP identifie les microARN actifs dans les diff\u00e9rents types de cellules du cerveau, r\u00e9v\u00e9lant comment ils r\u00e9duisent au silence les r\u00e9seaux de g\u00e8nes au cours de la neurogen\u00e8se.<\/p>\n","protected":false},"author":27,"featured_media":21602,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[79,132],"tags":[],"class_list":["post-21598","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news-fr","category-recherche","ibdm_team-team-101"],"acf":[],"_links":{"self":[{"href":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/wp-json\/wp\/v2\/posts\/21598","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/wp-json\/wp\/v2\/users\/27"}],"replies":[{"embeddable":true,"href":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/wp-json\/wp\/v2\/comments?post=21598"}],"version-history":[{"count":8,"href":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/wp-json\/wp\/v2\/posts\/21598\/revisions"}],"predecessor-version":[{"id":21621,"href":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/wp-json\/wp\/v2\/posts\/21598\/revisions\/21621"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/wp-json\/wp\/v2\/media\/21602"}],"wp:attachment":[{"href":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/wp-json\/wp\/v2\/media?parent=21598"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/wp-json\/wp\/v2\/categories?post=21598"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/wp-json\/wp\/v2\/tags?post=21598"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}