{"id":21567,"date":"2025-05-13T10:10:33","date_gmt":"2025-05-13T08:10:33","guid":{"rendered":"https:\/\/staging.wp-ibdm.nicolasg.fr\/?p=21567"},"modified":"2025-05-14T14:39:45","modified_gmt":"2025-05-14T12:39:45","slug":"auto-organisation-cellulaire-des-gastruloides","status":"publish","type":"post","link":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/auto-organisation-cellulaire-des-gastruloides\/","title":{"rendered":"Auto-organisation cellulaire des gastrulo\u00efdes"},"content":{"rendered":"\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t
\n\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t\t\t\t\t

Une collaboration entre l’\u00e9quipe du Professeur Lenne et le Centre de Physique Th\u00e9orique (CPT), dans le cadre du Centre Turing des Syst\u00e8mes Vivants, met en lumi\u00e8re le r\u00f4le des forces physiques dans l\u2019organisation des tissus embryonnaires pr\u00e9coces.<\/strong><\/p>

En travaillant sur des gastrulo\u00efdes, les chercheurs montrent que des flux tissulaires \u00e0 grande \u00e9chelle sont essentiels \u00e0 l\u2019\u00e9tablissement de l\u2019axe corporel. Loin d\u2019\u00eatre al\u00e9atoires, ces mouvements redistribuent les cellules en fonction de leur profil d\u2019expression g\u00e9nique, guidant ainsi leur organisation spatiale sans signal externe apparent.<\/p>

L\u2019\u00e9tude identifie l\u2019origine de ces flux dans des diff\u00e9rences de tension superficielle entre r\u00e9gions tissulaires, donnant lieu \u00e0 des \u00e9coulements comparables aux effets Marangoni observ\u00e9s en dynamique des fluides. La fusion contr\u00f4l\u00e9e de gastrulo\u00efdes distincts, ainsi que la mesure des angles de contact obtenus, ont permis de valider exp\u00e9rimentalement ces gradients de tension.<\/p>

Ainsi, l\u2019auto-organisation embryonnaire ne repose pas uniquement sur des programmes g\u00e9n\u00e9tiques pr\u00e9d\u00e9termin\u00e9s, mais r\u00e9sulte d\u2019une interaction dynamique entre forces m\u00e9caniques et identit\u00e9 cellulaire. Ce travail renforce l\u2019id\u00e9e que les principes physiques jouent un r\u00f4le structurant majeur dans la morphogen\u00e8se, avec des implications potentielles pour l\u2019ensemble des syst\u00e8mes d\u2019organo\u00efdes.<\/p>

Voir l’article du CNRS ici<\/a>.<\/p>

Gsell, S., Tlili, S., Merkel, M. et al.<\/i> Marangoni-like tissue flows enhance symmetry breaking of embryonic organoids.<\/a> Nat. Phys. <\/i> 21<\/b>, 644\u2013653 (2025).<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

\n\t\t\t\t\t\t
\n\t\t\t\t\t
\n\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t\t\t\t\t
\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\tRencontrez l'\u00e9quipe<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"

Des flux tissulaires de type Marangoni renforcent la rupture de sym\u00e9trie des organo\u00efdes embryonnaires.<\/p>\n","protected":false},"author":27,"featured_media":21572,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[79,132],"tags":[],"class_list":["post-21567","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news-fr","category-recherche","ibdm_team-team-101"],"acf":[],"_links":{"self":[{"href":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/wp-json\/wp\/v2\/posts\/21567","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/wp-json\/wp\/v2\/users\/27"}],"replies":[{"embeddable":true,"href":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/wp-json\/wp\/v2\/comments?post=21567"}],"version-history":[{"count":6,"href":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/wp-json\/wp\/v2\/posts\/21567\/revisions"}],"predecessor-version":[{"id":21596,"href":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/wp-json\/wp\/v2\/posts\/21567\/revisions\/21596"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/wp-json\/wp\/v2\/media\/21572"}],"wp:attachment":[{"href":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/wp-json\/wp\/v2\/media?parent=21567"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/wp-json\/wp\/v2\/categories?post=21567"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/wp-json\/wp\/v2\/tags?post=21567"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}