{"id":20228,"date":"2024-09-17T15:14:33","date_gmt":"2024-09-17T13:14:33","guid":{"rendered":"https:\/\/staging.wp-ibdm.nicolasg.fr\/?p=20228"},"modified":"2024-09-17T15:20:22","modified_gmt":"2024-09-17T13:20:22","slug":"la-regeneration-cardiaque-nest-pas-aussi-parfaite-quon-le-pretend","status":"publish","type":"post","link":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/la-regeneration-cardiaque-nest-pas-aussi-parfaite-quon-le-pretend\/","title":{"rendered":"La r\u00e9g\u00e9n\u00e9ration cardiaque n&#8217;est pas aussi parfaite qu&#8217;on le pr\u00e9tend"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"20228\" class=\"elementor elementor-20228 elementor-20227\" data-elementor-post-type=\"post\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-7aa502d elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"7aa502d\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-305ae95\" data-id=\"305ae95\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-8c26fb3 elementor-widget elementor-widget-text-editor\" data-id=\"8c26fb3\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p dir=\"auto\">L&#8217;infarctus du myocarde entra\u00eene la mort des cardiomyocytes et une alt\u00e9ration de la fonction cardiaque, suivie d&#8217;une forte pr\u00e9valence d&#8217;arythmies potentiellement mortelles, probablement dues \u00e0 des d\u00e9fauts de conduction. Contrairement aux mammif\u00e8res adultes, les souris nouveau-n\u00e9es peuvent r\u00e9g\u00e9n\u00e9rer un c\u0153ur fonctionnel apr\u00e8s un infarctus du myocarde. Dans cette \u00e9tude publi\u00e9e dans Nature Cardiovascular Research, Lucie Boulgakoff, de l&#8217;\u00e9quipe de Kelly, a d\u00e9couvert que la r\u00e9g\u00e9n\u00e9ration cardiaque apr\u00e8s un infarctus n\u00e9onatal chez la souris n&#8217;\u00e9tait pas si parfaite en ce qui concerne le c\u00e2blage \u00e9lectrique du c\u0153ur, d\u00e9crit comme le r\u00e9seau de fibres de Purkinjer. \u00c0 l&#8217;aide d&#8217;outils g\u00e9n\u00e9tiques sophistiqu\u00e9s, Lucie a montr\u00e9 qu&#8217;apr\u00e8s la r\u00e9g\u00e9n\u00e9ration cardiaque, les fibres de Purkinje pr\u00e9sentent une forme courte et rectangulaire, alors qu&#8217;elles sont minces et allong\u00e9es dans les c\u0153urs sham-op\u00e9r\u00e9s.   <\/p>\n<p dir=\"auto\"><strong>En r\u00e9sum\u00e9, chez les souris nouveau-n\u00e9es, apr\u00e8s un infarctus n\u00e9onatal, les cellules d\u00e9riv\u00e9es des trab\u00e9cules ventriculaires participent \u00e0 la r\u00e9paration du myocarde contractile, mais ce processus entra\u00eene une production excessive de fibres de Purkinje immatures formant un r\u00e9seau hyperplasique et conduisant \u00e0 une alt\u00e9ration de la conduction ventriculaire.<\/strong><\/p>\n<p dir=\"auto\">Boulgakoff L, Sturny R, Olejnickova V, Sedmera D, Kelly RG, Miquerol L. <a href=\"https:\/\/www.nature.com\/articles\/s44161-024-00530-z.epdf?sharing_token=753piGgZGlbaFVuLXQVLN9RgN0jAjWel9jnR3ZoTv0OfKJTm87f75puaI_mladwG7umc_0gsB3gKFH9DYhTPXU7N6iAibyDnHkqf0k3sX74zPMFZVj1FSrN8p3iZQnCzAtMwMKMsE_VJOc2I9VK4C913MLNwXch_61C5AuOzdYg%3D\" target=\"_blank\" rel=\"noopener\">Participation of ventricular trabeculae in neonatal cardiac regeneration leads to ectopic recruitment of Purkinje-like cells.<\/a> Nat Cardiovasc Res. 2024 Aug 28. doi: 10.1038\/s44161-024-00530-z. Epub ahead of print. Erratum in: Nat Cardiovasc Res. 2024 Sep 11. doi: 10.1038\/s44161-024-00548-3. PMID: 39198628.     <\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d1d3379 elementor-widget elementor-widget-button\" data-id=\"d1d3379\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/team\/controle-genetique-du-developpement-du-coeur\/\" target=\"_blank\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">RENCONTRER L'\u00c9QUIPE KELLY <\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>La r\u00e9g\u00e9n\u00e9ration cardiaque entra\u00eene une hyperplasie du r\u00e9seau de fibres de Purkinje et des troubles de la conduction ventriculaire.<\/p>\n","protected":false},"author":27,"featured_media":20232,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[79],"tags":[],"class_list":["post-20228","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news-fr","ibdm_team-team-5"],"acf":[],"_links":{"self":[{"href":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/wp-json\/wp\/v2\/posts\/20228","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/wp-json\/wp\/v2\/users\/27"}],"replies":[{"embeddable":true,"href":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/wp-json\/wp\/v2\/comments?post=20228"}],"version-history":[{"count":6,"href":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/wp-json\/wp\/v2\/posts\/20228\/revisions"}],"predecessor-version":[{"id":20241,"href":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/wp-json\/wp\/v2\/posts\/20228\/revisions\/20241"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/wp-json\/wp\/v2\/media\/20232"}],"wp:attachment":[{"href":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/wp-json\/wp\/v2\/media?parent=20228"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/wp-json\/wp\/v2\/categories?post=20228"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/wp-json\/wp\/v2\/tags?post=20228"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}