{"id":19760,"date":"2024-05-23T16:44:32","date_gmt":"2024-05-23T14:44:32","guid":{"rendered":"https:\/\/staging.wp-ibdm.nicolasg.fr\/?p=19760"},"modified":"2024-06-07T08:49:30","modified_gmt":"2024-06-07T06:49:30","slug":"la-douleur-chronique-commence-dans-lintestin","status":"publish","type":"post","link":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/la-douleur-chronique-commence-dans-lintestin\/","title":{"rendered":"La douleur chronique commence dans l&#8217;intestin"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"19760\" class=\"elementor elementor-19760 elementor-19759\" data-elementor-post-type=\"post\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-7aa502d elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"7aa502d\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-305ae95\" data-id=\"305ae95\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-8c26fb3 elementor-widget elementor-widget-text-editor\" data-id=\"8c26fb3\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>La douleur chronique est un probl\u00e8me de sant\u00e9 majeur, sans traitement efficace. La contribution du microbiote intestinal \u00e0 la pathogen\u00e8se de la douleur somatique (non visc\u00e9rale) chronique est peu document\u00e9e. <\/p>\n<p>Dans cette \u00e9tude, l&#8217;\u00e9quipe d&#8217;Aziz Moqrich (IBDM) a montr\u00e9 que les souris m\u00e2les d\u00e9pourvues de Myosine 1a (KO), mais pas les souris femelles, \u00e9lev\u00e9es dans des conditions d&#8217;h\u00e9bergement \u00e0 g\u00e9notype unique (KO-SGH) ont une pr\u00e9disposition \u00e0 d\u00e9velopper une douleur chronique en r\u00e9ponse \u00e0 une l\u00e9sion des tissus p\u00e9riph\u00e9riques. Dans ce mod\u00e8le murin, les auteurs ont mis en \u00e9vidence des alt\u00e9rations dans la composition du microbiote intestinal (dysbiose). Ils ont par la suite montr\u00e9 que cette dysbiose avait un r\u00f4le pr\u00e9pond\u00e9rant dans la vuln\u00e9rabilit\u00e9 des m\u00e2les KO-SGH \u00e0 d\u00e9velopper des douleurs chroniques, en perturbant la fonction des macrophages des ganglions de la racine dorsale (DRG). Ainsi, l\u2019\u00e9limination des macrophages du DRG pr\u00e9vient la chronicit\u00e9 de la douleur chez les souris KO-SGH. Ceci indique que les macrophages du DRG ont le potentiel de faire le lien entre des signaux du microbiote intestinal et la mise en place des douleurs chroniques.    <\/p>\n<p><strong>L&#8217;ensemble de ces r\u00e9sultats apporte de nouveaux concepts dans la biologie de la douleur, en r\u00e9v\u00e9lant le r\u00f4le des interactions g\u00e8ne-sexe-microbiote dans l\u2019\u00e9mergence de douleurs chroniques post-l\u00e9sionnelles. <\/strong><\/p>\n<p><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0889159124003970?via%3Dihub\" target=\"_blank\" rel=\"noopener\">Reynders et al., Gut microbiota promotes pain chronicity in Myosin1A deficient male mice, Brain Behavior and Immunity (2024), https:\/\/doi.org\/10.1016\/j.bbi.2024.05.010<\/a><\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d1d3379 elementor-widget elementor-widget-button\" data-id=\"d1d3379\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/team\/douleur-chronique-mecanismes-moleculaires-et-cellulaires\/\" target=\"_blank\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">RENCONTRER L'\u00c9QUIPE LENNE <\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>La dysbiose du microbiote intestinal favorise la douleur somatique chronique chez les souris m\u00e2les d\u00e9ficientes en Myo1a.<\/p>\n","protected":false},"author":27,"featured_media":19779,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[79],"tags":[],"class_list":["post-19760","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news-fr","ibdm_team-team-88"],"acf":[],"_links":{"self":[{"href":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/wp-json\/wp\/v2\/posts\/19760","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/wp-json\/wp\/v2\/users\/27"}],"replies":[{"embeddable":true,"href":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/wp-json\/wp\/v2\/comments?post=19760"}],"version-history":[{"count":11,"href":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/wp-json\/wp\/v2\/posts\/19760\/revisions"}],"predecessor-version":[{"id":19839,"href":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/wp-json\/wp\/v2\/posts\/19760\/revisions\/19839"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/wp-json\/wp\/v2\/media\/19779"}],"wp:attachment":[{"href":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/wp-json\/wp\/v2\/media?parent=19760"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/wp-json\/wp\/v2\/categories?post=19760"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/wp-json\/wp\/v2\/tags?post=19760"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}