{"id":17169,"date":"2023-07-12T12:57:07","date_gmt":"2023-07-12T10:57:07","guid":{"rendered":"https:\/\/staging.wp-ibdm.nicolasg.fr\/?p=17169"},"modified":"2023-07-21T09:47:22","modified_gmt":"2023-07-21T07:47:22","slug":"un-nouveau-mode-dorientation-de-la-division-cellulaire","status":"publish","type":"post","link":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/un-nouveau-mode-dorientation-de-la-division-cellulaire\/","title":{"rendered":"Un nouveau mode d&#8217;orientation de la division cellulaire"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"17169\" class=\"elementor elementor-17169 elementor-17168\" data-elementor-post-type=\"post\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-b972b03 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"b972b03\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-47b0b67\" data-id=\"47b0b67\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-367fb7e elementor-widget elementor-widget-text-editor\" data-id=\"367fb7e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>L&#8217;\u00e9tude de l&#8217;orientation de la division cellulaire dans les tissus et organes complexes des mammif\u00e8res, pertinents pour la physiologie et les maladies humaines, a g\u00e9n\u00e9ralement \u00e9t\u00e9 entrav\u00e9e par la difficult\u00e9 d&#8217;effectuer une imagerie avanc\u00e9e dans des mod\u00e8les animaux vivants et par les effets pl\u00e9iotropes plausibles des essais de perte de fonction. Par cons\u00e9quent, l&#8217;\u00e9tude des m\u00e9canismes d\u00e9taill\u00e9s r\u00e9gulant l&#8217;orientation du fuseau dans les tissus \u00e9pith\u00e9liaux des mammif\u00e8res en prolif\u00e9ration reste une entreprise ouverte.<\/p><p>Dans une \u00e9tude publi\u00e9e r\u00e9cemment dans Developmental Cell, Amlan Barai et Delphine Delacour de l&#8217;IBDM ont montr\u00e9 que la r\u00e9gulation de la longueur des microtubules peut servir de m\u00e9canisme cl\u00e9 pour que les fuseaux mitotiques d\u00e9tectent les formes cellulaires locales et les forces tissulaires afin de pr\u00e9server l&#8217;architecture \u00e9pith\u00e9liale des mammif\u00e8res, en documentant avec une haute r\u00e9solution temporelle et spatiale l&#8217;orientation des fuseaux ainsi que la dynamique des MT, la forme et la polarit\u00e9 des cellules dans des organo\u00efdes intestinaux de mammif\u00e8res en 3D.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-181da81 elementor-widget elementor-widget-heading\" data-id=\"181da81\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">En savoir plus<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c99ba7f elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"c99ba7f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Jad Saleh, Marc-Antoine Fardin, Amlan Barai, Matis Soleilhac, Olivia Frenoy, C\u00e9cile Gaston, Hongyue Cui, Tien Dang, No\u00e9mie Gaudin, Audrey Vincent, Nicolas Minc, Delphine Delacour, Length limitation of astral microtubules orients cell divisions in murine intestinal crypts, Developmental Cell, 2023, ISSN 1534-5807,<\/p>\n<p><a href=\"https:\/\/doi.org\/10.1016\/j.devcel.2023.06.004.\" target=\"_blank\" rel=\"noopener\">h<\/a><a style=\"font-family: var( --e-global-typography-text-font-family ), Sans-serif; font-size: var( --e-global-typography-text-font-size ); font-weight: var( --e-global-typography-text-font-weight ); letter-spacing: var( --e-global-typography-text-letter-spacing ); background-color: #ffffff;\" href=\"https:\/\/doi.org\/10.1016\/j.devcel.2023.06.004\" target=\"_blank\" rel=\"noopener\">ttps:\/\/doi.org\/10.1016\/j.devcel.2023.06.004<\/a><\/p>\n<p>\u00a0<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f2739ce elementor-widget elementor-widget-heading\" data-id=\"f2739ce\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Contact<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-dd243d8 elementor-widget elementor-widget-heading\" data-id=\"dd243d8\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-heading-title elementor-size-default\"><a href=\"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/member\/delphine-delacour\/\">Delphine Delacour<\/a><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Le groupe de D. Delacour propose un nouveau m\u00e9canisme pour le contr\u00f4le de l&#8217;orientation du fuseau planaire et de l&#8217;architecture du tissu monocouche dans l&#8217;\u00e9pith\u00e9lium intestinal.<\/p>\n","protected":false},"author":3,"featured_media":17175,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[132,79],"tags":[],"class_list":["post-17169","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-recherche","category-news-fr","ibdm_team-team-137"],"acf":[],"_links":{"self":[{"href":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/wp-json\/wp\/v2\/posts\/17169","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/wp-json\/wp\/v2\/comments?post=17169"}],"version-history":[{"count":16,"href":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/wp-json\/wp\/v2\/posts\/17169\/revisions"}],"predecessor-version":[{"id":17267,"href":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/wp-json\/wp\/v2\/posts\/17169\/revisions\/17267"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/wp-json\/wp\/v2\/media\/17175"}],"wp:attachment":[{"href":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/wp-json\/wp\/v2\/media?parent=17169"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/wp-json\/wp\/v2\/categories?post=17169"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/wp-json\/wp\/v2\/tags?post=17169"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}