{"id":16608,"date":"2023-06-06T15:37:12","date_gmt":"2023-06-06T13:37:12","guid":{"rendered":"https:\/\/staging.wp-ibdm.nicolasg.fr\/regulation-transcriptionnelle-de-la-respiration-cellulaire\/"},"modified":"2023-06-06T19:03:40","modified_gmt":"2023-06-06T17:03:40","slug":"regulation-transcriptionnelle-de-la-respiration-cellulaire","status":"publish","type":"post","link":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/regulation-transcriptionnelle-de-la-respiration-cellulaire\/","title":{"rendered":"R\u00e9gulation transcriptionnelle de la respiration cellulaire"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"16608\" class=\"elementor elementor-16608 elementor-16595\" data-elementor-post-type=\"post\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-d81b2fe elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"d81b2fe\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-6816595\" data-id=\"6816595\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-bd4330c elementor-widget elementor-widget-text-editor\" data-id=\"bd4330c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>La r\u00e9gulation transcriptionnelle de l&#8217;expression des g\u00e8nes de la phosphorylation oxydative mitochondriale est mal comprise. Dans une \u00e9tude r\u00e9cemment publi\u00e9e, Gabriela Poliacikova, Marine Barthez et d&#8217;autres chercheurs de l&#8217;IBDM ont montr\u00e9 que le facteur de transcription M1BP r\u00e9gule de mani\u00e8re transcriptionnelle l&#8217;expression des g\u00e8nes codant pour des composants essentiels \u00e0 l&#8217;assemblage et \u00e0 l&#8217;int\u00e9grit\u00e9 du complexe OXPHOS. En l&#8217;absence de la fonction M1BP, la quantit\u00e9 de complexes respiratoires mitochondriaux assembl\u00e9s est r\u00e9duite et les prot\u00e9ines OXPHOS s&#8217;agr\u00e8gent dans la matrice mitochondriale, d\u00e9clenchant une forte r\u00e9ponse de contr\u00f4le de la qualit\u00e9 des prot\u00e9ines.  <\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6255c6d elementor-widget elementor-widget-heading\" data-id=\"6255c6d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">En savoir plus<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6ba2d44 elementor-widget elementor-widget-text-editor\" data-id=\"6ba2d44\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Poliacikova G, Barthez M, Rival T, Aouane A, Luis NM, Richard F, Daian F, Brouilly N, Schnorrer F, Maurel-Zaffran C, Graba Y, Saurin AJ. <strong>Nat Commun. 2023 Jun 2;14(1):3187.<\/strong><\/p>\n<p><a href=\"https:\/\/doi.org\/10.1038\/s41467-023-38986-5\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.1038\/s41467-023-38986-5<\/a><\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e96df84 elementor-widget elementor-widget-heading\" data-id=\"e96df84\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Contact<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4a792c8 elementor-widget elementor-widget-heading\" data-id=\"4a792c8\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-heading-title elementor-size-default\"><a href=\"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/member\/andrew-saurin\/\">Andrew Saurin<\/a><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>En utilisant le muscle de vol de la drosophile, le groupe de Saurin et Graba identifie le facteur de transcription M1BP comme un nouveau r\u00e9gulateur majeur du m\u00e9tabolisme oxydatif mitochondrial.<\/p>\n","protected":false},"author":3,"featured_media":16598,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[132,79],"tags":[],"class_list":["post-16608","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-recherche","category-news-fr","ibdm_team-team-1"],"acf":[],"_links":{"self":[{"href":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/wp-json\/wp\/v2\/posts\/16608","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/wp-json\/wp\/v2\/comments?post=16608"}],"version-history":[{"count":4,"href":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/wp-json\/wp\/v2\/posts\/16608\/revisions"}],"predecessor-version":[{"id":16703,"href":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/wp-json\/wp\/v2\/posts\/16608\/revisions\/16703"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/wp-json\/wp\/v2\/media\/16598"}],"wp:attachment":[{"href":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/wp-json\/wp\/v2\/media?parent=16608"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/wp-json\/wp\/v2\/categories?post=16608"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/wp-json\/wp\/v2\/tags?post=16608"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}