{"id":14539,"date":"2023-01-11T18:08:02","date_gmt":"2023-01-11T17:08:02","guid":{"rendered":"https:\/\/staging.wp-ibdm.nicolasg.fr\/?p=14539"},"modified":"2023-01-11T20:39:49","modified_gmt":"2023-01-11T19:39:49","slug":"transformation-des-neuroblastes-en-oligodendrocytes","status":"publish","type":"post","link":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/transformation-des-neuroblastes-en-oligodendrocytes\/","title":{"rendered":"Transformation des neuroblastes en oligodendrocytes"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"14539\" class=\"elementor elementor-14539 elementor-14538\" data-elementor-post-type=\"post\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-6c6c942 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"6c6c942\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-5e82cd2\" data-id=\"5e82cd2\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-85276ac elementor-widget elementor-widget-text-editor\" data-id=\"85276ac\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"font-weight: 400;\">Dans cet article, l\u2019\u00e9quipe Durbec a montr\u00e9 que les neuroblastes, qui donnent naissance \u00e0 des neurones en condition physiologique, g\u00e9n\u00e8rent des oligodendrocytes my\u00e9linisants en condition pathologique. Ce changement de destin s\u2019op\u00e8re par la formation d&#8217;un \u00e9tat cellulaire transitoire coexprimant des marqueurs d\u2019identit\u00e9 neuronale et oligodendrocytaire. Cette conversion implique des ajustements fins des m\u00e9canismes de transcription et de traduction ainsi qu&#8217;une r\u00e9gulation du m\u00e9tabolisme des cellules et de leur comportement migratoire.  <\/span><\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ba95ba3 elementor-widget elementor-widget-heading\" data-id=\"ba95ba3\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">En savoir plus<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f90fe79 elementor-widget elementor-widget-text-editor\" data-id=\"f90fe79\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2589004222013748\" target=\"_blank\" rel=\"noopener\"><span style=\"font-weight: 400;\">El Waly B, Bertet C, Paris M, Falque M, Milpied P, Magalon K, Cayre M, Durbec P. <\/span><span style=\"font-weight: 400;\">Neuroblasts contribute to oligodendrocytes generation upon demyelination in the adult mouse brain.<\/span><span style=\"font-weight: 400;\"> iScience. 2022 Sep 13;25(10):105102. <\/span><\/a><\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3a377da elementor-widget elementor-widget-heading\" data-id=\"3a377da\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Contact<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3de3dc1 elementor-widget elementor-widget-heading\" data-id=\"3de3dc1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-heading-title elementor-size-default\"><a href=\"https:\/\/staging.wp-ibdm.nicolasg.fr\/member\/pascale-durbec\/\">Pascale Durbec<\/a><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Les neuroblastes peuvent g\u00e9n\u00e9rer des oligodendrocytes my\u00e9linisants en condition pathologique. <\/p>\n","protected":false},"author":3,"featured_media":14542,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[132],"tags":[],"class_list":["post-14539","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-recherche","ibdm_team-team-17"],"acf":[],"_links":{"self":[{"href":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/wp-json\/wp\/v2\/posts\/14539","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/wp-json\/wp\/v2\/comments?post=14539"}],"version-history":[{"count":5,"href":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/wp-json\/wp\/v2\/posts\/14539\/revisions"}],"predecessor-version":[{"id":14624,"href":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/wp-json\/wp\/v2\/posts\/14539\/revisions\/14624"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/wp-json\/wp\/v2\/media\/14542"}],"wp:attachment":[{"href":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/wp-json\/wp\/v2\/media?parent=14539"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/wp-json\/wp\/v2\/categories?post=14539"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/wp-json\/wp\/v2\/tags?post=14539"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}