{"id":11401,"date":"2022-07-11T10:50:51","date_gmt":"2022-07-11T08:50:51","guid":{"rendered":"https:\/\/staging.wp-ibdm.nicolasg.fr\/des-facteurs-chromatiniens-prc1-assurent-la-robustesse-de-la-differenciation-des-neurones\/"},"modified":"2022-07-11T11:11:25","modified_gmt":"2022-07-11T09:11:25","slug":"des-facteurs-chromatiniens-prc1-assurent-la-robustesse-de-la-differenciation-des-neurones","status":"publish","type":"post","link":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/des-facteurs-chromatiniens-prc1-assurent-la-robustesse-de-la-differenciation-des-neurones\/","title":{"rendered":"Des facteurs chromatiniens PRC1 assurent la robustesse de la diff\u00e9renciation des neurones"},"content":{"rendered":"<p>Au cours du d\u00e9veloppement une grande diversit\u00e9 de types neuronaux est produite et ils maintiennent par la suite leur identit\u00e9 tout au long de la vie de l\u2019animal. Comment cela est r\u00e9alis\u00e9 de mani\u00e8re fiable malgr\u00e9 le bruit dans l\u2019expression des g\u00e8nes, la variabilit\u00e9 g\u00e9n\u00e9tique ou les perturbations de l\u2019environnement reste mal compris. Dans cette \u00e9tude l\u2019\u00e9quipe Bertrand a analys\u00e9 le bruit pr\u00e9sent dans le programme de diff\u00e9renciation des neurones en utilisant des approches d\u2019imagerie quantitative. Ils ont observ\u00e9 que des facteurs chromatiniens PRC1 prot\u00e8gent les neurones contre le bruit interne, les perturbations g\u00e9n\u00e9tiques et le stress environnemental.   <\/p>\n<h3>En savoir plus<\/h3>\n<p><a href=\"https:\/\/journals.plos.org\/plosgenetics\/article?id=10.1371\/journal.pgen.1010209\" target=\"_blank\" rel=\"noopener\">Bordet G., Couillault C., Soulavie F., Filippopoulou K. and Bertrand V. (2022). PRC1 chromatin factors strengthen the consistency of neuronal cell fate specification and maintenance in <i>C. elegans<\/i>. PLoS Genetics 18, e1010209.   DOI: 10.1371\/journal.pgen.1010209. PMID: 35604893.<\/a><\/p>\n<style>\/*! elementor - v3.6.7 - 03-07-2022 *\/\n.elementor-heading-title{padding:0;margin:0;line-height:1}.elementor-widget-heading .elementor-heading-title[class*=elementor-size-]>a{color:inherit;font-size:inherit;line-height:inherit}.elementor-widget-heading .elementor-heading-title.elementor-size-small{font-size:15px}.elementor-widget-heading .elementor-heading-title.elementor-size-medium{font-size:19px}.elementor-widget-heading .elementor-heading-title.elementor-size-large{font-size:29px}.elementor-widget-heading .elementor-heading-title.elementor-size-xl{font-size:39px}.elementor-widget-heading .elementor-heading-title.elementor-size-xxl{font-size:59px}<\/style>\n<h3>Contact<\/h3>\n<p>\t\t\tVincent Bertrand<\/p>\n","protected":false},"excerpt":{"rendered":"<p>L\u2019\u00e9quipe Bertrand a identifi\u00e9 un role pour des facteurs chromatiniens PRC1 dans la robustesse de l\u2019identit\u00e9 des neurones contre le bruit dans l\u2019expression des g\u00e8nes et les perturbations environnementales.<\/p>\n","protected":false},"author":3,"featured_media":8893,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[79,132],"tags":[],"class_list":["post-11401","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news-fr","category-recherche","ibdm_team-team-104"],"acf":[],"_links":{"self":[{"href":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/wp-json\/wp\/v2\/posts\/11401","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/wp-json\/wp\/v2\/comments?post=11401"}],"version-history":[{"count":3,"href":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/wp-json\/wp\/v2\/posts\/11401\/revisions"}],"predecessor-version":[{"id":11404,"href":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/wp-json\/wp\/v2\/posts\/11401\/revisions\/11404"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/wp-json\/wp\/v2\/media\/8893"}],"wp:attachment":[{"href":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/wp-json\/wp\/v2\/media?parent=11401"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/wp-json\/wp\/v2\/categories?post=11401"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/staging.wp-ibdm.nicolasg.fr\/fr\/wp-json\/wp\/v2\/tags?post=11401"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}