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Three additional projects funded!
Congratulations to Ana Reynders, Christopher Thomas & Benjamin Prud’homme.
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Marc-Éric Perrin rewarded by the Collège de France
His innovative contributions to neural development modeling have been recognized. Congratulations!
Striatal cholinergic interneuron development and autism
Altered developmental trajectory of striatal cholinergic interneurons: a substrate of autism-linked repetitive behavior
Congratulation to our young doctors!
5 motivated and talented students successfully defended their thesis.
Precancer: the influence of the nervous system
Sympathetic nerve plasticity slows the formation of precancerous pancreatic lesions.
Make it bigger to see it better!
New protocol development for expansion microscopy on Xenopus samples.
Laurent Kodjabachian receives a Wellcome Discovery Grant!
Congratulations to Laurent and his team “Biology of Ciliated Epithelia”!
Julia Schaeffer has been selected by the ATIP-Avenir programme!
A great opportunity to launch your research team, congratulations Julia!
Nested genes are top influencers
Genes nested in introns can influence the transcription of their host genes.
Cardiac defects in a mouse model of Duchenne dystrophy (Mdx)
New study challenges the link between Purkinje fibers and heart arrhythmias in Duchenne muscular dystrophy.
Microtubules: The Architect of Muscles
Microtubules guide mitochondria into proximity of myofibrils during muscle development.
Sarcomeres: look, they divide
Mother sarcomeres divide into daughter sarcomeres to mediate muscle growth.
ERC Advanced Grant for Thomas Lecuit’s GeoMorpho project!
We’re thrilled to share that Thomas Lecuit has been awarded a prestigious ERC Advanced Grant for his new project.
Mini-Symposium: Linking Neural Development, Human Disease, and Evolution
Join Us on September 29, 2025 at the Hexagone, Luminy, in Marseille.
Sham Tlili, winner of the CNRS 2025 bronze medal
A distinction that rewards a promising and already fruitful scientific career.
Titin rules insect muscles for a flight or a walk
Genetics, in vivo imaging and force measurements combined with
mathematical modelling reveal how titin tailors sarcomere specialisations in
Drosophila.
A new technique reveals the secrets of microRNA activity
In vivo AGO-APP identifies active microRNAs in the different cell types of the brain revealing how they cooperatively silence gene networks during neurogenesis.
Tissue flows enhance symmetry breaking of embryonic organoids
New insights into cell self-organization mechanisms in gastruloids.
Spatial transcriptomics of adult Drosophila
Single-molecule mRNA detection method reveals brain cell types and mRNA localisation patterns in muscle cells of adult Drosophila.
Trap then kill: coordination key to fly larvae survival
Using ROS, larvae coordinate trapping harmful gut bacteria with a valve, then kill them with antimicrobial peptides.
How insects deploy their wings
A pressure increase leads to both unfolding and expansion of the wing upon pupal emergence.
Looking back at recent recruitments
Congratulations to Youmna Atieh, Baptiste Libé-Philippot, Léo Guignard, Emmanuelle Leblanc and Séverine Platel.
Aziz Moqrich wins the 2024 Grand Prix for Research in Provence
Congratulations on this achievement!
Julia Schaeffer honored by the French Academy of Sciences
Julia has been awarded the Prix 2024 des Grandes Avancées Françaises en Biologie for her work on neuronal regeneration.
We Are Recruiting Group Leaders
The Institut de Biologie du Développement de Marseille (IBDM) is inviting applications for group leader positions. We are seeking innovative researchers who aim to address fundamental questions in biology, including the development, function, and dynamics of complex biological systems.
Shaping Life: An International Conference on Developmental Biology
The upcoming edition of Shaping Life, scheduled for June 3-6, 2025, will be held in Cassis.
Baptiste Libé-Philippot receives the Prix Paoletti 2024
Baptiste Libé-Philippot was awarded the Prix Paoletti 2024 by CNRS Biology and the CNRS Foundation. Congratulations!
30 years of IBDM
A moment of communion in the love of Science.
Outreach Spotlight: Our Researchers Engage Beyond the Institute!
Discover how members of our community are making an impact outside the walls of the institute through public outreach and creative initiatives.
Muscle formation at the head/trunk interface
Trapezius muscle development requires crosstalk between pharyngeal and somitic mesoderm in the early mouse embryo.
Hidden asymmetries in the brain
An asymmetric molecular program hides behind the production of bilaterally symmetric axons.
ANR and FRM Grant Successes: Highlights from Our IBDM members
We’re pleased to share some great news about our researchers’ achievements! Several projects from our teams have been selected for funding by the ANR and FRM, highlighting their hard work and innovative research.
The IBDM welcomes three new research groups!
We would like to extend a warm welcome to Julia Schaeffer, Baptiste Libé-Philippot and Christopher Thomas.
Congratulations to Baptiste Libé-Philippot on winning an ERC Starting Grant
Elucidating the cellular and molecular divergence of the human cerebellum.
Cardiac regeneration is not as perfect as it has been claimed
Cardiac regeneration leads to hyperplastic Purkinje fiber network in association with ventricular conduction disorders.
A touch of softness to facilitate differentiation of human induced pluripotent stem cells
Tuning of substrate stiffness enhances mesendoderm/endoderm hiPSC differentiation by modifying their epithelial properties.
IBDM Portraits – Claire Bertet
I like the thinking, the interaction with my colleagues and the intellectual freedom that this job gives me.
Repair of cardiac coronary using collaterals
During cardiac regeneration, collaterals form rapidly to perfuse the infarcted area and help repair the coronary artery.
2024 SFBD PhD Thesis Prizes
Congratulations to Sanjay and Jérôme!
Muscle development under pressure
The transcriptional regulator Tono coordinates myogenesis in Drosophila by sensing pressure build-up in muscle nuclei.
Cancer innervation: the role of Schwann cells
Schwann cells undergo adaptive reprogramming to promote successful neuronal remodeling in pancreatic cancer.
IBDM Portraits – Ahmed Fatmi
For me, building a qPCR technical platform is much more than a technical achievement.
CNRS Podcast : Gastrulation, the first stage of life
Pierre-François Lenne focuses on gastrulation, an essential stage in the creation of the first tissues.
Recent promotions @IBDM
Celebrating the accomplishments of IBDM members.
Speed up muscle and neurons patterns analysis with PatternJ
A new tool for ImageJ/Fiji to analyze automatically patterns found muscles, neurons and more.
Chronic pain starts from the gut
Alterations in gut microbiota composition promotes chronic somatic pain in Myosin1a-deficient male mice.
Festival EXPLORE
Come explore science with scientists from Marseille!
IBDM Portraits – Camille Boutin
I’m fascinated by the notion of micro-chimerism, which shows that we can harbor cells from our mothers in our bodies.
High School Students in the Lab
Qiyan Mao organized a day aimed at introducing students to the world of research.
And yet it diffuses!
Free diffusion of Wnt ligands can polarize target cells at distance in C. elegans embryos.
IBDM is recruiting 9 PhD students
Launch your research career with a doctoral contract from Aix-Marseille University through ED62 or through NeuroSchool.
Lost in translation: Vangl2 short and long
Translation starts with a Methionine: True, but not always, as revealed in a study of the PCP component Vangl2.
Emma Legait at the 5th edition of the Neurostories
The brain: a permanent work in progress
Redefining epithelial junctions with nanoscopy
Lenne and Le Bivic teams show that intestinal adherens junctions are very different from the textbook picture.
When microbiota shape the host gustatory properties
How the larval microbiota modulates the sensory modalities of future adults?
A look back at recent promotions
Congratulations to Sylvie Aguillon, Eric Rollée, Ahmed Fatmi, Claire Chardes, Cédric Maurange and Delphine Delacour.
A warm welcome to the new Ph.D. students
Welcome to our Ph.D. students; we are excited to witness the accomplishments you will achieve during your doctoral journey!
Zooming in on a wave of tissue invagination
Understanding how adhesion and contractility drive a wave of tissue invagination from a subcellular perspective.
Serotonin on Mechanics and Morphogenesis Mood
Sanjay Karki from Thomas Lecuit’s team reports that serotonin signaling regulates actomyosin contractility during embryonic axis morphogenesis in insect and bird.
Tiny Avengers of Science Uncovering Stem Cell Secrets
Watch how model organisms are used at the IBDM to investigate normal and derailed stem cell trajectories.
The Evolution of an Agricultural Pest: A Sweet Shift
Sweet Temptations: How Drosophila Suzukii’s Love for Sugar is Causing Havoc in the Agriculture Industry.
Tafalgie Therapeutics Laureate of the EIC Accelerator 2023
The IBDM spin-off rewarded for its innovation in a non-opioid biologic drug for pain relief.
The Ruban Rose Avenir Award honours Flavio Maina’s Research at IBDM and His Move to CRCM
We extend our heartfelt congratulations to Flavio Maina and his team for this distinction and warmly thank them for their exceptional dedication to the search of more effective breast cancer treatments.
IBDM welcomes a new research group!
We are delighted to welcome Leo Guignard and his new research group ‘Computer Science, Morphogenesis and Variability’ to IBDM.
Recent achievements and promotions
Celebrating the accomplishments of IBDM members.
Join the IBDM for your internship!
Seeking for your Master internship? The IBDM seems like the right place to do it? Check out our offers.
Youth & Science: Delta Festival
Delta Festival 2023: Music, themed villages, and a touch of IBDM to shine under the Marseille sun.
IBDM teams win 4 grants from ANR, INCa and Fondation ARC
Congratulations to Robert Kelly, Frank Schnorrer, Cédric Maurange, Bianca Habermann and Delphine Delacour!
Alcohol and brain development
The Mann team identifies the microRNA-17-5p as responsible for alcohol-related brain connectivity defects.
Qiyan Mao succeeded in the CNRS Researchers Competition (CRCN) 2023
From AFM-Téléthon Postdoc Fellow to CNRS Researcher: Qiyan Mao is advancing human muscle research through molecular and tissue mechanics approaches.
Congratulation to our young and talented doctors!
3 motivated and talented students successfully defended their thesis between February and July 2023.
IBDM welcomes a new research group!
We are delighted to welcome Delphine Delacour and her new research group ‘Epithelial monolayer morphogenesis’ to IBDM.
A new model for cell division orientation
The Delacour group proposes a new mechanism for the control of planar spindle orientation and monolayered tissue architecture in the intestinal epithelium.
IBDM gets schoolchildren excited about science!
IBDM Marseille inspires young minds: engaging primary school children on childhood cancer (“Contre le cancer, j’apporte ma pierre”) and interacting with high school students through immersive experiences (DECLICS).
Transcriptional regulation of cellular respiration
The Saurin/Graba group discover the transcription factor M1BP as new major regulator of oxidative metabolism.
Embark on a PhD journey at the IBDM
Launch your research career with a doctoral contract from Aix-Marseille University through ED62 or through NeuroSchool.
Optical manipulation reveals cell junction mechanics
Epithelial tissues under tension: a study explores how individual cells deform and respond to forces.
Looking back at recent recruitments and promotions
Congratulations to Ruth Souza, Elise Arbeille, Fabien Durbesson, Vincent Bertrand, Léopold Kurz, Olivier Zugasti, Nathalie Caruso, Cédric Matthews, Florian Roguet, Fabienne Lamballe.
Congratulation to our young and talented doctors!
5 motivated and talented students successfully defended their thesis between September 2022 and January 2023.
An ERC Synergy Grant for the BREAKDANCE project
Lenne group, together with 3 other groups, Merkel (CNRS), Trivedi (EMBL), and Ruprecht (CRG) – embark on BREAKDANCE
PAINTing muscle with nanobodies positions protein giants
Drosophila sarcomeres visualised at super-resolution with the help of nanobodies and single molecule blinks.
How disruption drives change
Interaction between tight junction formation and gastrulation signals regulates mesendoderm differentiation in hiPSCs
Show me your rhythm!
We introduce an algorithm, Phasik, for extracting the phases of biological systems by clustering partial temporal networks.
MYC and MET, the ‘Bonnie and Clyde’ in the liver
A new genetic cooperation acting on liver cancer has been uncovered in patients and functionally documented in vivo
Several awards for IBDM members !
Congrats to Aziz Moqrich, Sophie Chauvet and Stefan Harmansa.
The Marseille Developmental Biology Institute is recruiting group leaders
The IBDM invites applications for group leader positions. We seek researchers
who define and address fundamental questions in biology, including the
development, the function, and the dynamics of complex biological systems.
Transformation of neuroblasts into oligodendrocytes
Neuroblasts can generate myelinating oligodendrocytes in pathological states.
Visit of Thierry Lhermitte to the IBDM
Aziz Moqrich team hosted the actor and sponsor of the medical Research Foundation FRM, Thierry Lhermitte.
Organizing the organizers
A new perspective to tackle the very complex cell polarity field.
NeuroStories 2022: Emprise de tête
Mike Altounian presented his work on the effects of alcohol on neural circuit development at Neurostories 2022.
Robert G. Kelly, recipient of the Lamonica Grand Prize for Cardiology
Robert G. Kelly is the recipient of the Lamonica Grand Prize for Cardiology – Fondation pour la Recherche Biomédicale PCL 2022 from the French Academy of Sciences.
Establishing regional identity in the cardiac outflow tract
Complementary PPARγ and NOTCH pathways pattern outflow tract myocardium
10 IBDM projects have been selected for funding by the ANR
Congratulations to Pascale Durberc, Lucile Miquerol, Aziz Moqrich, Thomas Lecuit, Benjamin Prud’homme, Laurent Fasano, Laurent Kodjabachian, Robert Kelly, Camille Boutin and Sham Tlili.
Self-organisation of human muscles in a dish
Human muscle cells self-organise into defined fiber bundles in vitro even without the presence of external cues !
Epigenetic factors regulate tumor hierarchy
PRC2 and MLL1/2 cooperate to guide developmental programs recapitulated in tumors.
PRC1 chromatin factors ensure the robustness of neuronal differentiation
The Bertrand team shows that PRC1 chromatin factors play a role in the robustness of neuronal fate against gene expression noise and environmental perturbations.
Frank Schnorrer elected as EMBO member
EMBO elects 67 new members and associate members. They join the community of more than 1,900 leading life scientists in Europe and beyond.
Cell-state transitions and collective cell movement generate an endoderm-like region in gastruloids
The Lenne team published in Elife: using gastruloids –3D aggregates of mouse embryonic stem cells- they study at cellular resolution the specification of the endoderm.
Targeted Tshz3 deletion in corticostriatal circuit components segregates core autistic behaviors
Nos résultats apportent un éclairage nouveau sur l’implication du circuit corticostrié dans les TSA.
Nervous But Sympathetic !
In this study, the Mann team showed that pancreatic cancer development promotes the sprouting and growth of sympathetic axons.
Astrocyte-intrinsic and –extrinsic activities of the Fat1 cadherin regulate astrocyte development and angiogenesis in the mouse retina
The Helmbacher team identified the Fat1 Cadherin as a novel regulator of retinal vascular integrity, and investigated the underlying mechanisms.
