In a collaborative study published in Development, the teams of Vincent Bertrand and Pierre-François Lenne analyze the role played by Wnt ligands in the divisions that generate neurons during nervous system development. Using time-controlled perturbations and quantitative imaging, they established that Wnt ligands regulate the shape of neuronal progenitors and their asymmetric divisions in an instructive manner. Wnt ligands act via a Frizzled receptor and an APC protein that is asymmetrically localized at the cortex of progenitors and unequally inherited by the daughter cells.

To know more :

• Wnt ligands regulate the asymmetric divisions of neuronal progenitors in C. elegans embryos

Development 2020 147: dev183186 doi: 10.1242/dev.183186 Published 6 April 2020

Shilpa Kaur, Pauline Mélénec, Sabrina Murgan, Guillaume Bordet, Pierre Recouvreux, Pierre-François Lenne, Vincent Bertrand

• Contact

Vincent Bertrand – vincent.bertrand@univ-amu.fr
Pierre-François Lenne – pierre-francois.lenne@univ-amu.fr